It's the middle of the night. You're driving on a lonely road. Suddenly, out of nowhere, another car hits you. When you wake up there's shattered glass all over the pavement, your friends are injured, and the other car is gone. You're disoriented, hurting--but when you see the ambulance's flashing red and blue lights, you know help has arrived.

Emily Johnson, her boyfriend Bobby and their friends Clare and Jude are recent college grads driving cross-country, taking a last vacation together before they face the "real" world. An accident leaves them hurt and stranded on a lonely Louisiana road. When the ambulance arrives, it whisks them to Mercy Hospital. With a minimal staff and many of its floors empty, the hospital is an eerie place--but that's only the beginning.

The staff is conducting inhuman experiments on helpless patients under the instruction of Dr. Benway, a direct descendant of the infamous New Orleans family that committed atrocities in the 19th century